The first practical point is that we need to be careful how we treat this verse. It is not presented as a standalone statement. While “it is appointed unto man…” is certainly true, keeping verses in context is one of the keys to Biblical Interpretation.
Sacrifice is willing. Punishment is deserved. Jesus takes our punishment, willingly as a sacrifice. It’s not that His death was demanded by the Law. It’s that ours is deserved by it.